AustralieFrV1, Main, Exploration, bibRecord, 007A01

Chikungunya Virus Arthritis in Adult Wild-Type Mice

Identifieur interne : 007A01 ( Main/Exploration ); précédent : 007A00; suivant : 007A02

Chikungunya Virus Arthritis in Adult Wild-Type Mice

Auteurs : Joy Gardner [Australie] ; Itaru Anraku [Australie] ; Thuy T. Le [Australie] ; Thibaut Larcher [France] ; Lee Major [Australie] ; Pierre Roques [France] ; Wayne A. Schroder [Australie] ; Stephen Higgs [États-Unis] ; Andreas Suhrbier [Australie]

Source :

Journal of virology [ 0022-538X ] ; 2010.

RBID : Pascal:10-0421809

Descripteurs français

Pascal (Inist)
- Virus Chikungunya, Souris, Arthrite.

English descriptors

KwdEn :
- Arthritis, Chikungunya virus, Mouse.

Abstract

Chikungunya virus is a mosquito-borne arthrogenic alphavirus that has recently reemerged to produce the largest epidemic ever documented for this virus. Here we describe a new adult wild-type mouse model of chikungunya virus arthritis, which recapitulates the self-limiting arthritis, tenosynovitis, and myositis seen in humans. Rheumatic disease was associated with a prolific infiltrate of monocytes, macrophages, and NK cells and the production of monocyte chemoattractant protein 1 (MCP-1), tumor necrosis factor alpha (TNF-α), and gamma interferon (IFN-γ). Infection with a virus isolate from the recent Reunion Island epidemic induced significantly more mononuclear infiltrates, proinflammatory mediators, and foot swelling than did an Asian isolate from the 1960s. Primary mouse macrophages were shown to be productively infected with chikungunya virus; however, the depletion of macrophages ameliorated rheumatic disease and prolonged the viremia. Only 1 μg of an unadjuvanted, inactivated, whole-virus vaccine derived from the Asian isolate completely protected against viremia and arthritis induced by the Reunion Island isolate, illustrating that protection is not strain specific and that low levels of immunity are sufficient to mediate protection. IFN-α treatment was able to prevent arthritis only if given before infection, suggesting that IFN-α is not a viable therapy. Prior infection with Ross River virus, a related arthrogenic alphavirus, and anti-Ross River virus antibodies protected mice against chikungunya virus disease, suggesting that individuals previously exposed to Ross River virus should be protected from chikungunya virus disease. This new mouse model of chikungunya virus disease thus provides insights into pathogenesis and a simple and convenient system to test potential new interventions.

Url:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2916516

Affiliations:

Le document en format XML

<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en" level="a">Chikungunya Virus Arthritis in Adult Wild-Type Mice</title>
<author><name sortKey="Gardner, Joy" sort="Gardner, Joy" uniqKey="Gardner J" first="Joy" last="Gardner">Joy Gardner</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Queensland Institute of Medical Research, Australian Centre for International and Tropical Health</s1>
<s2>Brisbane</s2>
<s3>AUS</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>9 aut.</sZ>
</inist:fA14>
<country>Australie</country>
<wicri:noRegion>Brisbane</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Anraku, Itaru" sort="Anraku, Itaru" uniqKey="Anraku I" first="Itaru" last="Anraku">Itaru Anraku</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Queensland Institute of Medical Research, Australian Centre for International and Tropical Health</s1>
<s2>Brisbane</s2>
<s3>AUS</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>9 aut.</sZ>
</inist:fA14>
<country>Australie</country>
<wicri:noRegion>Brisbane</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Le, Thuy T" sort="Le, Thuy T" uniqKey="Le T" first="Thuy T." last="Le">Thuy T. Le</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Queensland Institute of Medical Research, Australian Centre for International and Tropical Health</s1>
<s2>Brisbane</s2>
<s3>AUS</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>9 aut.</sZ>
</inist:fA14>
<country>Australie</country>
<wicri:noRegion>Brisbane</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Larcher, Thibaut" sort="Larcher, Thibaut" uniqKey="Larcher T" first="Thibaut" last="Larcher">Thibaut Larcher</name>
<affiliation wicri:level="3"><inist:fA14 i1="02"><s1>Institut National de Recherche Agronomique, Unité Mixte de Recherche 703, Ecole Nationale Vétérinaire</s1>
<s2>Nantes</s2>
<s3>FRA</s3>
<sZ>4 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><region type="region">Pays de la Loire</region>
<region type="old region">Pays de la Loire</region>
<settlement type="city">Nantes</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Major, Lee" sort="Major, Lee" uniqKey="Major L" first="Lee" last="Major">Lee Major</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Queensland Institute of Medical Research, Australian Centre for International and Tropical Health</s1>
<s2>Brisbane</s2>
<s3>AUS</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>9 aut.</sZ>
</inist:fA14>
<country>Australie</country>
<wicri:noRegion>Brisbane</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Roques, Pierre" sort="Roques, Pierre" uniqKey="Roques P" first="Pierre" last="Roques">Pierre Roques</name>
<affiliation wicri:level="1"><inist:fA14 i1="03"><s1>CEA, Division of Immuno-Virolog, Institute of Emerging Diseases and Innovative Therapies</s1>
<s2>Fontenay-aux-Roses</s2>
<s3>FRA</s3>
<sZ>6 aut.</sZ>
</inist:fA14>
<country>France</country>
<wicri:noRegion>Fontenay-aux-Roses</wicri:noRegion>
<wicri:noRegion>Institute of Emerging Diseases and Innovative Therapies</wicri:noRegion>
<wicri:noRegion>Fontenay-aux-Roses</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Schroder, Wayne A" sort="Schroder, Wayne A" uniqKey="Schroder W" first="Wayne A." last="Schroder">Wayne A. Schroder</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Queensland Institute of Medical Research, Australian Centre for International and Tropical Health</s1>
<s2>Brisbane</s2>
<s3>AUS</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>9 aut.</sZ>
</inist:fA14>
<country>Australie</country>
<wicri:noRegion>Brisbane</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Higgs, Stephen" sort="Higgs, Stephen" uniqKey="Higgs S" first="Stephen" last="Higgs">Stephen Higgs</name>
<affiliation wicri:level="2"><inist:fA14 i1="04"><s1>Department of Pathology, University of Texas Medical Branch</s1>
<s2>Galveston, Texas</s2>
<s3>USA</s3>
<sZ>8 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<placeName><region type="state">Texas</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Suhrbier, Andreas" sort="Suhrbier, Andreas" uniqKey="Suhrbier A" first="Andreas" last="Suhrbier">Andreas Suhrbier</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Queensland Institute of Medical Research, Australian Centre for International and Tropical Health</s1>
<s2>Brisbane</s2>
<s3>AUS</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>9 aut.</sZ>
</inist:fA14>
<country>Australie</country>
<wicri:noRegion>Brisbane</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><inist:fA14 i1="05"><s1>Griffith Medical Research College, Griffith University</s1>
<s2>Brisbane</s2>
<s3>AUS</s3>
<sZ>9 aut.</sZ>
</inist:fA14>
<country>Australie</country>
<wicri:noRegion>Brisbane</wicri:noRegion>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">INIST</idno>
<idno type="inist">10-0421809</idno>
<date when="2010">2010</date>
<idno type="stanalyst">PASCAL 10-0421809 INIST</idno>
<idno type="RBID">Pascal:10-0421809</idno>
<idno type="wicri:Area/PascalFrancis/Corpus">002400</idno>
<idno type="wicri:Area/PascalFrancis/Curation">003B93</idno>
<idno type="wicri:Area/PascalFrancis/Checkpoint">002565</idno>
<idno type="wicri:explorRef" wicri:stream="PascalFrancis" wicri:step="Checkpoint">002565</idno>
<idno type="wicri:doubleKey">0022-538X:2010:Gardner J:chikungunya:virus:arthritis</idno>
<idno type="wicri:Area/Main/Merge">008033</idno>
<idno type="wicri:source">PMC</idno>
<idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2916516</idno>
<idno type="RBID">PMC:2916516</idno>
<idno type="wicri:Area/Pmc/Corpus">001A19</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">001A19</idno>
<idno type="wicri:Area/Pmc/Curation">001877</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">001877</idno>
<idno type="wicri:Area/Pmc/Checkpoint">002629</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">002629</idno>
<idno type="wicri:Area/Ncbi/Merge">000794</idno>
<idno type="wicri:Area/Ncbi/Curation">000794</idno>
<idno type="wicri:Area/Ncbi/Checkpoint">000794</idno>
<idno type="wicri:doubleKey">0022-538X:2010:Gardner J:chikungunya:virus:arthritis</idno>
<idno type="wicri:Area/Main/Merge">007516</idno>
<idno type="wicri:Area/Main/Curation">007A01</idno>
<idno type="wicri:Area/Main/Exploration">007A01</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">Chikungunya Virus Arthritis in Adult Wild-Type Mice</title>
<author><name sortKey="Gardner, Joy" sort="Gardner, Joy" uniqKey="Gardner J" first="Joy" last="Gardner">Joy Gardner</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Queensland Institute of Medical Research, Australian Centre for International and Tropical Health</s1>
<s2>Brisbane</s2>
<s3>AUS</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>9 aut.</sZ>
</inist:fA14>
<country>Australie</country>
<wicri:noRegion>Brisbane</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Anraku, Itaru" sort="Anraku, Itaru" uniqKey="Anraku I" first="Itaru" last="Anraku">Itaru Anraku</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Queensland Institute of Medical Research, Australian Centre for International and Tropical Health</s1>
<s2>Brisbane</s2>
<s3>AUS</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>9 aut.</sZ>
</inist:fA14>
<country>Australie</country>
<wicri:noRegion>Brisbane</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Le, Thuy T" sort="Le, Thuy T" uniqKey="Le T" first="Thuy T." last="Le">Thuy T. Le</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Queensland Institute of Medical Research, Australian Centre for International and Tropical Health</s1>
<s2>Brisbane</s2>
<s3>AUS</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>9 aut.</sZ>
</inist:fA14>
<country>Australie</country>
<wicri:noRegion>Brisbane</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Larcher, Thibaut" sort="Larcher, Thibaut" uniqKey="Larcher T" first="Thibaut" last="Larcher">Thibaut Larcher</name>
<affiliation wicri:level="3"><inist:fA14 i1="02"><s1>Institut National de Recherche Agronomique, Unité Mixte de Recherche 703, Ecole Nationale Vétérinaire</s1>
<s2>Nantes</s2>
<s3>FRA</s3>
<sZ>4 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><region type="region">Pays de la Loire</region>
<region type="old region">Pays de la Loire</region>
<settlement type="city">Nantes</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Major, Lee" sort="Major, Lee" uniqKey="Major L" first="Lee" last="Major">Lee Major</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Queensland Institute of Medical Research, Australian Centre for International and Tropical Health</s1>
<s2>Brisbane</s2>
<s3>AUS</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>9 aut.</sZ>
</inist:fA14>
<country>Australie</country>
<wicri:noRegion>Brisbane</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Roques, Pierre" sort="Roques, Pierre" uniqKey="Roques P" first="Pierre" last="Roques">Pierre Roques</name>
<affiliation wicri:level="1"><inist:fA14 i1="03"><s1>CEA, Division of Immuno-Virolog, Institute of Emerging Diseases and Innovative Therapies</s1>
<s2>Fontenay-aux-Roses</s2>
<s3>FRA</s3>
<sZ>6 aut.</sZ>
</inist:fA14>
<country>France</country>
<wicri:noRegion>Fontenay-aux-Roses</wicri:noRegion>
<wicri:noRegion>Institute of Emerging Diseases and Innovative Therapies</wicri:noRegion>
<wicri:noRegion>Fontenay-aux-Roses</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Schroder, Wayne A" sort="Schroder, Wayne A" uniqKey="Schroder W" first="Wayne A." last="Schroder">Wayne A. Schroder</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Queensland Institute of Medical Research, Australian Centre for International and Tropical Health</s1>
<s2>Brisbane</s2>
<s3>AUS</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>9 aut.</sZ>
</inist:fA14>
<country>Australie</country>
<wicri:noRegion>Brisbane</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Higgs, Stephen" sort="Higgs, Stephen" uniqKey="Higgs S" first="Stephen" last="Higgs">Stephen Higgs</name>
<affiliation wicri:level="2"><inist:fA14 i1="04"><s1>Department of Pathology, University of Texas Medical Branch</s1>
<s2>Galveston, Texas</s2>
<s3>USA</s3>
<sZ>8 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<placeName><region type="state">Texas</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Suhrbier, Andreas" sort="Suhrbier, Andreas" uniqKey="Suhrbier A" first="Andreas" last="Suhrbier">Andreas Suhrbier</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Queensland Institute of Medical Research, Australian Centre for International and Tropical Health</s1>
<s2>Brisbane</s2>
<s3>AUS</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>9 aut.</sZ>
</inist:fA14>
<country>Australie</country>
<wicri:noRegion>Brisbane</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><inist:fA14 i1="05"><s1>Griffith Medical Research College, Griffith University</s1>
<s2>Brisbane</s2>
<s3>AUS</s3>
<sZ>9 aut.</sZ>
</inist:fA14>
<country>Australie</country>
<wicri:noRegion>Brisbane</wicri:noRegion>
</affiliation>
</author>
</analytic>
<series><title level="j" type="main">Journal of virology</title>
<title level="j" type="abbreviated">J. virol.</title>
<idno type="ISSN">0022-538X</idno>
<imprint><date when="2010">2010</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
<seriesStmt><title level="j" type="main">Journal of virology</title>
<title level="j" type="abbreviated">J. virol.</title>
<idno type="ISSN">0022-538X</idno>
</seriesStmt>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Arthritis</term>
<term>Chikungunya virus</term>
<term>Mouse</term>
</keywords>
<keywords scheme="Pascal" xml:lang="fr"><term>Virus Chikungunya</term>
<term>Souris</term>
<term>Arthrite</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">Chikungunya virus is a mosquito-borne arthrogenic alphavirus that has recently reemerged to produce the largest epidemic ever documented for this virus. Here we describe a new adult wild-type mouse model of chikungunya virus arthritis, which recapitulates the self-limiting arthritis, tenosynovitis, and myositis seen in humans. Rheumatic disease was associated with a prolific infiltrate of monocytes, macrophages, and NK cells and the production of monocyte chemoattractant protein 1 (MCP-1), tumor necrosis factor alpha (TNF-α), and gamma interferon (IFN-γ). Infection with a virus isolate from the recent Reunion Island epidemic induced significantly more mononuclear infiltrates, proinflammatory mediators, and foot swelling than did an Asian isolate from the 1960s. Primary mouse macrophages were shown to be productively infected with chikungunya virus; however, the depletion of macrophages ameliorated rheumatic disease and prolonged the viremia. Only 1 μg of an unadjuvanted, inactivated, whole-virus vaccine derived from the Asian isolate completely protected against viremia and arthritis induced by the Reunion Island isolate, illustrating that protection is not strain specific and that low levels of immunity are sufficient to mediate protection. IFN-α treatment was able to prevent arthritis only if given before infection, suggesting that IFN-α is not a viable therapy. Prior infection with Ross River virus, a related arthrogenic alphavirus, and anti-Ross River virus antibodies protected mice against chikungunya virus disease, suggesting that individuals previously exposed to Ross River virus should be protected from chikungunya virus disease. This new mouse model of chikungunya virus disease thus provides insights into pathogenesis and a simple and convenient system to test potential new interventions.</div>
</front>
</TEI>
<affiliations><list><country><li>Australie</li>
<li>France</li>
<li>États-Unis</li>
</country>
<region><li>Pays de la Loire</li>
<li>Texas</li>
</region>
<settlement><li>Nantes</li>
</settlement>
</list>
<tree><country name="Australie"><noRegion><name sortKey="Gardner, Joy" sort="Gardner, Joy" uniqKey="Gardner J" first="Joy" last="Gardner">Joy Gardner</name>
</noRegion>
<name sortKey="Anraku, Itaru" sort="Anraku, Itaru" uniqKey="Anraku I" first="Itaru" last="Anraku">Itaru Anraku</name>
<name sortKey="Le, Thuy T" sort="Le, Thuy T" uniqKey="Le T" first="Thuy T." last="Le">Thuy T. Le</name>
<name sortKey="Major, Lee" sort="Major, Lee" uniqKey="Major L" first="Lee" last="Major">Lee Major</name>
<name sortKey="Schroder, Wayne A" sort="Schroder, Wayne A" uniqKey="Schroder W" first="Wayne A." last="Schroder">Wayne A. Schroder</name>
<name sortKey="Suhrbier, Andreas" sort="Suhrbier, Andreas" uniqKey="Suhrbier A" first="Andreas" last="Suhrbier">Andreas Suhrbier</name>
<name sortKey="Suhrbier, Andreas" sort="Suhrbier, Andreas" uniqKey="Suhrbier A" first="Andreas" last="Suhrbier">Andreas Suhrbier</name>
</country>
<country name="France"><region name="Pays de la Loire"><name sortKey="Larcher, Thibaut" sort="Larcher, Thibaut" uniqKey="Larcher T" first="Thibaut" last="Larcher">Thibaut Larcher</name>
</region>
<name sortKey="Roques, Pierre" sort="Roques, Pierre" uniqKey="Roques P" first="Pierre" last="Roques">Pierre Roques</name>
</country>
<country name="États-Unis"><region name="Texas"><name sortKey="Higgs, Stephen" sort="Higgs, Stephen" uniqKey="Higgs S" first="Stephen" last="Higgs">Stephen Higgs</name>
</region>
</country>
</tree>
</affiliations>
</record>

Pour manipuler ce document sous Unix (Dilib)

EXPLOR_STEP=$WICRI_ROOT/Wicri/Asie/explor/AustralieFrV1/Data/Main/Exploration

HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 007A01 | SxmlIndent | more

HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 007A01 | SxmlIndent | more

Pour mettre un lien sur cette page dans le réseau Wicri

{{Explor lien
   |wiki=    Wicri/Asie
   |area=    AustralieFrV1
   |flux=    Main
   |étape=   Exploration
   |type=    RBID
   |clé=     Pascal:10-0421809
   |texte=   Chikungunya Virus Arthritis in Adult Wild-Type Mice
}}

This area was generated with Dilib version V0.6.33.
Data generation: Tue Dec 5 10:43:12 2017. Site generation: Tue Mar 5 14:07:20 2024

Serveur d'exploration sur les relations entre la France et l'Australie

Chikungunya Virus Arthritis in Adult Wild-Type Mice

Chikungunya Virus Arthritis in Adult Wild-Type Mice

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

	Serveur d'exploration sur les relations entre la France et l'Australie
	Attention, ce site est en cours de développement ! Attention, site généré par des moyens informatiques à partir de corpus bruts. Les informations ne sont donc pas validées.